• Barber DM, Schönberger M, Burgstaller J, Levitz J, Weaver CD, Isacoff EY, Baier H, and Trauner D. (2015) Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO) Chem. Sci., doi: 10.1039/C5SC04084A

  • Trads JB, Burgstaller J, Laprell L, Konrad D, de la Osa de la Rosa L, Weaver CD, Baier H, Trauner D, Barber DM. (2016) Optical control of GIRK channels using visible light. Org. Biomol. Chem. doi: 10.1039/c6ob02153k

  • Wieting JM, Vadukoot AK, Sharma S, Abney KK, Bridges TM, Daniels JS, Morrison RD, Wickman K, Weaver CD, Hopkins CR. (2017) Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators. ACS Chem Neurosci. doi: 10.1021/acschemneuro.7b00217

  • Schubert M, Stichel J, Du Y, Tough IR, Sliwoski G, Meiler J, Cox HM, Weaver CD, Beck-Sickinger AG. (2017) Identification and Characterization of the First Selective Y4 Receptor Positive Allosteric Modulator. J Med Chem. doi: 10.1021/acs.jmedchem.7b00976

  • Prael FJ III, Chen R, Li Z, Reed CW, Lindsley CW, Weaver CD, Swale DR (2018) Use of chemical probes to explore the toxicological potential of the K+/Cl- cotransporter (KCC) as a novel insecticide target to control the primary vector of dengue and Zika virus, Aedes aegypti. Pest. Biochem. Physiol. doi: 10.1016/j.pestbp.2018.03.019

  • Abney KK, Ramos-Hunter SJ, Romaine IM, Goodwin SJ, Sulikowski GA, Weaver CD (2018) Selective Activation of N,N'‐Diacyl Rhodamine Pro‐fluorophores Paired with Releasing Enzyme, Porcine Liver Esterase (PLE). Chemistry. doi: 10.1002/chem.201801409

  • Kharade SV, Kurata H, Bender A, Blobaum AL, Figueroa EE, Duran AM, Kramer M, Days E, Vinson P, Flores D, Satlin LM, Meiler J, Weaver CD, Lindsley CW, Hopkins CR, Denton JS. (2018) Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992. Mol Pharmacol. pii: mol.118.112359. doi: 10.1124/mol.118.112359

  • Dutter BF, Ender AE, Sulikowski GA, Weaver CD. (2018) Rhodol-based Thallium Sensors for Cellular Imaging of Potassium Channel Activity. Org. Biomol. Chem., http://dx.doi.org/10.1039/C8OB01098F

  • Kozek KA, Du Y, Sharma S, Prael FJ, Spitznagel BD, Kharade SV, Denton JS, Hopkins CR, and Weaver CD. (2018) Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-gated, Inwardly-rectifying, Potassium (GIRK) Channels. ACS Chem Neurosci. DOI: 10.1021/acschemneuro.8b00287

  • Abney KK, Bubser M, Du Y, Kozek KA, Bridges TM, Linsdley CW, Daniels JS, Morrison RD, Wickman K, Hopkins CR, Jones CK, Weaver CD. (2019) Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models. ACS Chem Neurosci. 10(3):1294-1299. doi: 10.1021/acschemneuro.8b00370

  • Vo BN, Abney KK, Anderson A, Marron Fernandez de Velasco E, Benneyworth MA, Daniels JS, Morrison RD, Hopkins CR, Weaver CD, Wickman K. (2019) VU0810464, a non-urea GIRK channel activator, exhibits enhanced selectivity for neuronal GIRK channels and reduces stress-induced hyperthermia in mice. Br J Pharmacol. doi: 10.1111/bph.14671.

  • Chen R, Prael FJ 3rd, Li Z, Delpire E, Weaver CD, Swale DR. (2019) Functional Coupling of K+-Cl- Cotransporter (KCC) to GABA-Gated Cl- Channels in the Central Nervous System of Drosophila melanogaster Leads to Altered Drug Sensitivities. ACS Chem Neurosci. doi: 10.1021/acschemneuro.8b00697.

  • Siricilla S, Knapp KM, Rogers JH, Berger C, Shelton EL, Mi D, Vinson P, Condon J, Paria BC, Reese J, Sheng Q, Herington JL. (2019) Comparative analysis of myometrial and vascular smooth muscle cells to determine optimal cells for use in drug discovery. Pharmacol Res.104268. doi: 10.1016/j.phrs.2019.104268.

  • Porter JD, Vivas O, Weaver CD, Alsafran A, DiMilo E, Arnold LA, Dickson EJ, Dockendorff C. (2019) An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders. Bioorg Med Chem Lett. 29(23):126681. doi: 10.1016/j.bmcl.2019.126681.

  • Trads JB, Hüll K, Matsuura BS, Laprell L, Fehrentz T, Görldt N, Kozek KA, Weaver CD, Klöcker N, Barber DM, Trauner D. (2019) Sign Inversion in Photopharmacology: Incorporation of Cyclic Azobenzenes in Photoswitchable Potassium Channel Blockers and Openers. Angew Chem Int Ed Engl. 58(43):15421-15428. doi: 10.1002/anie.201905790.

  • Afzal A, Figueroa EE, Kharade SV, Bittman K, Matlock BK, Flaherty DK, Denton JS. (2019) The LRRC8 volume-regulated anion channel inhibitor, DCPIB, inhibits mitochondrial respiration independently of the channel. Physiol Rep. 7(23):e14303. doi: 10.14814/phy2.14303.

  • Figueroa EE, Kramer M, Strange K, Denton JS. (2019) CysLT1 receptor antagonists pranlukast and zafirlukast inhibit LRRC8-mediated volume regulated anion channels independently of the receptor. Am J Physiol Cell Physiol. 317(4):C857-C866. doi: 10.1152/ajpcell.00281.2019.

  • Kharade SV, Sanchez-Andres JV, Fulton MG, Shelton EL, Blobaum AL, Engers DW, Hofmann CS, Dadi PK, Lantier L, Jacobson DA, Lindsley CW, Denton JS. (2019) Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063. J Pharmacol Exp Ther. 370(3):350-359. doi: 10.1124/jpet.119.257204.

  • Iwaki Y, Yashiro K, Kokubo M, Mori T, Wieting JM, McGowan KM, Bridges TM, Engers DW, Denton JS, Kurata H, Lindsley CW. (2019) Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249. Bioorg Med Chem Lett. 29(13):1601-1604. doi: 10.1016/j.bmcl.2019.04.048.

  • Aretz CD, Morwitzer MJ, Sanford AG, Hogan AM, Portillo MV, Kharade SV, Kramer M, McCarthey JB, Trigueros RR, Piermarini PM, Denton JS, Hopkins CR. (2019) Discovery and Characterization of 2-Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)- N-(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 (AeKir1) Channel. ACS Infect Dis. 5(6):917-931. doi: 10.1021/acsinfecdis.8b00368.

  • Sammons MF, Kharade SV, Filipski KJ, Boehm M, Smith AC, Shavnya A, Fernando DP, Dowling MS, Carpino PA, Castle NA, Zellmer SG, Antonio BM, Gosset JR, Carlo A, and Denton JS. (2019) Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors. ACS Med Chem Lett. 9(2): 125–130. doi: 10.1021/acsmedchemlett.7b00481.

  • Afzal A, Figueroa EE, Kharade SV, Bittman K, Matlock BK, Flaherty DK, and Denton JS. (2019) The LRRC8 volume‐regulated anion channel inhibitor, DCPIB, inhibits mitochondrial respiration independently of the channel. Physiol Rep. 7(23): e14303. doi: 10.14814/phy2.14303.

  • Horning KJ, Joshi P, Nitin R, Balachandran RC, Yanko FM, Kim K, Christov P, Aschner M, Sulikowski GA, Weaver CD, Bowman AB. (2020) Identification of a selective manganese ionophore that enables non-lethal quantification of cellular manganese. J Biol Chem. pii: jbc.RA119.009781. doi: 10.1074/jbc.RA119.009781.

  • Aggarwal G, Zarrow JE, Mashhadi Z, Flynn CR, Vinson P, Weaver CD, Davies SS. (2020) Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D. J Biol Chem. pii: jbc.RA120.013362. doi: 10.1074/jbc.RA120.013362.

  • Spitznagel BD, Mishra NM, Qunies AM, Prael FJ 3rd, Du Y, Kozek KA, Lazarenko RM, Denton JS, Emmitte KA, Weaver CD. (2020) VU0606170, a Selective Slack Channels Inhibitor, Decreases Calcium Oscillations in Cultured Cortical Neurons. ACS Chem Neurosci. 11(21):3658-3671. PMID: 33143429.

  • Schüß C, Vu O, Schubert M, Du Y, Mishra NM, Tough IR, Stichel J, Weaver CD, Emmitte KA, Cox HM, Meiler J, and Beck-Sickinger AG, (2020) The Highly Selective Y4 Receptor Antagonist Binds in a Deep, Allosteric Binding Pocket. J Med Chem. 2021 Mar 11;64(5):2801-2814. doi: 10.1021/acs.jmedchem.0c02000. PMID: 33595306.

  • Aretz CD, Kharade SV, Chronister K, Trigueros RR, Martinez Rodriguez EJ, Piermarini PM, Denton JS, Hopkins CR. (2021) Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 (AeKir) Channel and Larvicides. ChemMedChem. 16(2):319-327. doi: 10.1002/cmdc.202000598.

  • Figueroa EE, Denton JS. (2021) Zinc pyrithione activates the volume-regulated anion channel through an antioxidant-sensitive mechanism. Am J Physiol Cell Physiol. 320(6):C1088-C1098. doi: 10.1152/ajpcell.00070.2021.